Thiamine pyrophosphate (tpp) is a coenzyme derived from vitamin b1 that is used by the enzyme pyruvate dehydrogenase to convert pyruvate to acetyl coa. tpp has a relatively acidic proton that can prod

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Thiamine pyrophosphate (tpp) is a coenzyme partial from vitamin b1 that is used by the enzyme pyruvate dehydrogenase to exercise pyruvate to acetyl coa. tpp has a relatively acidic proton that can yield a carbanion which can act as an electron suppress and aid in the decarboxylation of α–keto acids. the primary stride of the pyruvate dehydrogenase contrivance is the reaction of pyruvate delay tpp, followed by decarboxylation. this gives an interposed that can donate a two-carbon ace to the lipoamide prosthetic class to frame acetyl lipoamide. substantiate the relieve interposed by dragging in the amend make.

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