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Pomajzl 3.2

Clinical Outcome Research Article

 Between November 2, 2005 and July 25, 2011, a clinical study was completed to determine how efficient Topiramate was for treating cocaine dependence (Johnson et al. 2013).

The study is deemed to be a clinical trial because 142 cocaine-dependent adults took part in a twelve-week trial. Participants were either given placebo or Topiramate. The primary outcome of the study was the difference from the baseline in proportion of the nonuse cocaine days. The secondary outcome was the amount and time of urinary cocaine-free weeks.

Topiramate was administered with a low dosage to begin. The study began with cocaine-addicted individuals receiving 50mg each days. Weekly the amount was increased with the maximum amount being dispersed during week between five and six. The maximum amount, 300mg, was give through the remainder of the study.

As a result, Topiramate was much more effective than placebo concerning the amount of nonuse days regarding the cocaine dependency. Topiramate associated highly with more urinary cocaine-free weeks than placebo. Topiramate also decreased cravings of cocaine use and improved the functioning of those who were dependent to cocaine (Johnson et al.  2013).

 Sperry 3.2

The study, Bipolarity In depressive patients without histories of diagnosis of bipolar disorder and the use of the Mood Disorder Questionnaire for detecting bipolarity, was an intriguing read. This study focused on clinical features of bipolar, as the study determines underdiagnosed patients who are bipolar. This study was clinical trial based on the fact that there were a total of 147 patients, groups were compared and there was a single result (Wang, 2008).

                The groups in this study were large unlike a smaller study that you would find in a qualitative analysis studies. The participants were primarily separated into two groups at first. The two groups were prior diagnosed as bipolar and a group that had never been diagnosed, but had experienced depression. Then after further evaluation the bipolar group was classified further as either bipolar I, Bipolar II, suicidal, alcohol abuse, panic disorders, etc. The group that was labeled as unipolar using the Mood Disorder Questionnaire were reviewed further to assess frequencies of clinical features of depression. (Wang, 2008).

                The result from the study found that frequencies in some clinical features with bipolar diagnosed patients were higher than estimated. Features that were above normal that was detected in this study were postpartum depression, early age of onset, mood lability, brief depressive episode and recurrent depression.

                This study showed the importance to outcome research, the facts showed that many patients that reported depression are usually diagnosed with depression and/or anxiety. Bipolar can be misdiagnosed, as this study shows it is important to interview and collect all of your data before diagnosing a patient.


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